Shared Epitope Molecular Basis, Immunological Role, and Clinical Implications in Autoimmune Diseases
Introduction Autoimmune diseases develop when the immune system erroneously targets self-tissues, leading to chronic inflammation and tissue damage. Among the strongest genetic risk factors identified for autoimmune conditions, particularly rheumatoid arthritis (RA), are allelic variations of the HLA-DRB1 gene. The Shared Epitope […]