Regorafenib A Multi-Kinase Inhibitor for Refractory Cancers – Mechanism, Clinical Applications, and Emerging Insights Introduction Regorafenib is an orally administered multikinase inhibitor used in the treatment of various refractory cancers. Approved by the U.S. FDA in 2012, it offers a new line […]
Cumulative Dose Concept, Clinical Relevance, and Implications in Long-Term Drug Therapy Introduction The term cumulative dose refers to the total quantity of a drug or radiation that a patient receives over a period of time. It is a crucial parameter in pharmacology, […]
Cardiotoxicity Mechanisms, Risk Factors, and Clinical Implications in Modern Medicine Introduction Cardiotoxicity refers to damage inflicted on the heart muscle (myocardium) by chemical substances, particularly pharmaceutical drugs or environmental toxins. This condition is increasingly significant in clinical practice due to the widespread […]