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Shared epitope hypothesis

Applied Science in Biology

HLA-DRB1 Genetic Variability, Immunological Roles, and Clinical Implications

Innovative Research JournalsSeptember 20, 2025

Introduction The human leukocyte antigen (HLA) system plays a fundamental role in adaptive immunity by presenting antigenic peptides to T lymphocytes. Among its components, the HLA-DRB1 gene stands out due to its extensive polymorphism and strong associations with autoimmune diseases. HLA-DRB1, located […]

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